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 Safe, effective and oral antiparasitics against protozoal infections

The purine nucleoside platform is based on known and novel sugar- and purine ring scaffolds. The nucleoside platform contains lead molecules for different indications. Proof of concept data at different stages (in vitro to in vivo) are available for various indications: Leishmania, Chagas, Nagana disease, Dourine, Surra, Blackhead, Cryptosporidium, and Toxoplasma species. Proof of concept in various mouse models As an example, we found 3’-deoxytubercidin analogues to be highly potent trypanocides against T. brucei spp. One analogue served as proof-of-concept in relevant mouse model of T. brucei infection. This derivative, 3’-deoxytubercidin, displays curative activity in both acute and CNS-stage infection in mice, highlighting that it is able to cross the blood-brain-barrier, likely a class effect.
· Socio buscado Partnering We seek development and marketing partners interested in developing nucleoside analogues as anti-parasitic against protozoal infections.

Sven Arnouts
sven.arnouts@ugent.be
+32 495 707 334

Una iniciativa de

Vet + i
Vetdivulga
Ayuda PTR2020- 001197 financiada por:

UNION EUROPEA - FONDO EUROPEO DE DESARROLLO REGIONAL