Vetinnova
PORTAL DE REFERENCIA SOBRE I+D+i
EN SANIDAD ANIMAL
 

Área Personal

Acceso al área privada de la web
Búsqueda de texto en la web

fbus

CREA TU PERFIL Grupo de Investigación
Grupo de Investigación
CREA TU PERFIL Empresa
Empresa

 Nanoparticle system for improved pulmonary delivery

An endogenous protein that strongly improves lung cell permeability for cytosolic delivery SP-B is an endogenous protein that, as a key component in lung surfactant, strongly improves lung cell permeability for cytosolic delivery. SP-B, combined with our nanoparticle technology, can be applied to deliver various cargo (such as proteins, drug molecules and siRNA) to pulmonary cells. Proof of concept SP-B’s functionality was integrated in a proteolipid nanoparticle by enveloping an siRNA loaded dextrane core with a specific composition of lipids and SP-B. The developed nanocomposites have a low in vivo toxicity and show a high uptake by alveolar macrophages.
· Socio buscado Partnering We seek partnerships to explore SP-B technology for delivery of macromolecules in disease of interest or for benchmarking/validation studies for local pulmonary applications.

Destacados pie

Vetdivulga
Una iniciativa de

Vet + i