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Nanoparticle system for improved pulmonary delivery

An endogenous protein that strongly improves lung cell permeability for cytosolic delivery SP-B is an endogenous protein that, as a key component in lung surfactant, strongly improves lung cell permeability for cytosolic delivery. SP-B, combined with our nanoparticle technology, can be applied to deliver various cargo (such as proteins, drug molecules and siRNA) to pulmonary cells. Proof of concept SP-B’s functionality was integrated in a proteolipid nanoparticle by enveloping an siRNA loaded dextrane core with a specific composition of lipids and SP-B. The developed nanocomposites have a low in vivo toxicity and show a high uptake by alveolar macrophages.

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Una iniciativa de

Ayuda PTR2022-001249 financiada por:

UNION EUROPEA - FONDO EUROPEO DE DESARROLLO REGIONAL

Área Personal

Nanoparticle system for improved pulmonary delivery