Search Partner Service

In this section, you can add new consortium or search for partners or R&D&i project proposals in Animal Health that are already defined or in their initial stage. The scope of the projects can be national, European or international calls, or private projects.

Safe, effective and oral antiparasitics against protozoal infections

The purine nucleoside platform is based on known and novel sugar- and purine ring scaffolds. The nucleoside platform contains lead molecules for different indications. Proof of concept data at different stages (in vitro to in vivo) are available for various indications: Leishmania, Chagas, Nagana disease, Dourine, Surra, Blackhead, Cryptosporidium, and Toxoplasma species. Proof of concept in various mouse models As an example, we found 3’-deoxytubercidin analogues to be highly potent trypanocides against T. brucei spp. One analogue served as proof-of-concept in relevant mouse model of T. brucei infection. This derivative, 3’-deoxytubercidin, displays curative activity in both acute and CNS-stage infection in mice, highlighting that it is able to cross the blood-brain-barrier, likely a class effect.

Sven Arnouts
sven.arnouts@ugent.be
+32 495 707 334

volver

Imprimir

Una iniciativa de

Ayuda PTR2022-001249 financiada por:

UNION EUROPEA - FONDO EUROPEO DE DESARROLLO REGIONAL

Área Personal

Safe, effective and oral antiparasitics against protozoal infections