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Entry portal through the intestinal barrier

Controlled transfer of biological compounds through the intestinal (mucosal) barrier via targeting of the compound to a defined receptor (APN) on the epithelium. Via selective transcytosis through the intestinal barrier various functions at the level of the intestinal epithelium and beyond can be modulated: i) antigens can be efficiently presented to the gut associated lymphoid tissue (GALT) leading to a protective mucosal immune response and ii) drugs or drug-containing (nano-)particles can be transferred and delivered across the intestinal barrier. Proof of concept for oral vaccination in the pig Oral immunization of pigs with rabbit anti-APN antibodies leads to higher antibody responses when compared to immunization with a control rabbit antibody.

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Una iniciativa de

Ayuda PTR2022-001249 financiada por:

UNION EUROPEA - FONDO EUROPEO DE DESARROLLO REGIONAL

Área Personal

Entry portal through the intestinal barrier