Antiparasitic chemotherapy of zoonoses

Our group develops the research line ´New chemical entities for drug discovery´ in the field of parasitic diseases, especially those produced by pathogenic protozoa. Since its creation, the group has developed several series of compounds that are highly active against various parasitic protozoa (T. cruzi, T. brucei spp., T. vaginalis, Leishmania spp., Plasmodium spp.). Several lead compounds also demonstrated in vivo efficacy in mouse models of trypanosomiasis, leishmaniasis, and malaria. At present, the group continues the study of these lead compounds, as well as the development of new ones, designed to attack specific targets of these parasites. The groups is primarily working on the design and synthesis of new active molecules. We collaborate with groups from the CSIC or other institutions in Spain and abroad (computational chemists, biochemists, parasitologists, pharmaceutical technologists, crystallographers) to achieve the proposed objectives.